Good News in History, August 31

And, on this day 25 years ago, the Good News Network made positive news available on the web for the first time. Geri Weis-Corbley, the founder, worked in TV news, freelancing for CNN and other media companies, until the advent of the internet when she created what is now the #1 source for inspiring news. […]

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Sensor-based early detection of age-related diseases from home

Researchers have demonstrated how sensors that record movement patterns could help detect health problems in the elderly, including old-age depression, risk of falls or cognitive impairment, at an early stage. In the future, this could help seniors to live a self-determined life at home for longer and relieve increasing pressure on the healthcare system.

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Access to paid sick leave linked to lower mortality rate among US adult workers

Access to paid sick leave is linked to a lower rate of mortality among US working age men and women, according to new research.

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Music helps patients with dementia connect with loved ones

People with dementia often lose their ability to communicate verbally with loved ones. But a new study shows how that gap can be bridged with a new music intervention. Music memories remain in the brain after patients lose language. A live ensemble played music from a patient's youth. This created an emotional connection between a patient and their caregiver by allowing them to interact with the music together via singing, dancing and playing simple instruments.

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How the brain's housekeeper malfunctions during bacterial meningitis

Bacterial meningitis is a life-threatening infectious disease of the brain that leaves many survivors with long-lasting neurological impairments. Now, researchers show in a study on rats that the brain's tool for waste clearance, the glymphatic system, malfunctions during bacterial meningitis, causing a buildup of toxic garbage that damages brain cells.

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Brief exposure to rapamycin has the same anti-aging effects as lifelong treatment

Brief exposure with rapamycin has the same positive effects on lifespan and health in old age as a lifelong treatment, researchers show in fruit flies and mice. Rapamycin is currently the most promising anti-aging drug. To maximize the medicine's effectiveness, it is often administered for life. However, even at low doses used to prevent age-related decline, side effects can occur. Therefore, the shorter duration of treatment may make it more likely to be used in humans.

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Half of moms of kids with autism have high depressive symptoms

About 50% of all mothers of children with autism spectrum disorder (ASD) had elevated levels of depressive symptoms over 18 months, while rates were much lower (6% to 13.6%) for mothers with neurotypical children in the same period, researchers report.

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Mom Moved to Tears as Disabled Son Finally Gets to Play in the Sea Thanks to Beach Wheelchair –WATCH

A little boy finally got to play in the sea, thanks to the use of a beach wheelchair—and his laughter brought his mom to tears. Joey has quadriplegic cerebral palsy, which affects both of his arms and legs, and sometimes his torso and face. The two-year-old suffers with very bad sensory issues and cannot stand […]

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Innovative strategy targeting a blood protein for the therapeutic treatment of Alzheimer's disease

Researchers have identified a blood protein that plays a key role in the pathogenesis of Alzheimer's disease (AD). Their findings reveal an innovative strategy in reducing the risk of AD development and ameliorating disease pathologies in individuals living with AD.

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Physical activity may have a stronger role than genes in longevity

A new study asked whether associations between physical activity and sedentary time with death varied based on different levels of genetic predisposition for longevity.

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Danes lost 30,000 years of healthy life due to COVID-19 in the first year of the pandemic, study finds

Every Dane who died from COVID-19 in 2020 lost an average of 13 healthy years of life, according to new figures that show the burden of the disease.

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Revealing roles of dementia proteins in normal memory

New research has revealed how the tau protein, a critical element in the formation of Alzheimer's disease, is also involved in normal learning processes in the healthy brain -- potentially providing a focal point for future drug therapies.

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Poor heart health predicts premature brain aging

By estimating people's brain age from MRI scans using machine learning, a team of researchers has identified multiple risk factors for a prematurely aging brain.

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Modified bladder cancer treatment shows promise in animal studies

Many bladder cancer patients cannot tolerate the strong side effects of the gold standard treatment. Researchers have found a way to minimize those side effects and are poised to move into clinical trials.

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When Alzheimer's degrades cells that cross hemispheres, visual memory suffers

New research reveals cells that span brain hemispheres to coordinate activity in visual processing centers and shows that Alzheimer's degrades their structure and therefore their function.

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Interdisciplinary panel offers solutions to improve recruitment for Alzheimer's clinical trials

Researchers aim to develop solutions to overcome some of the steepest barriers to clinical trial recruitment.

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Researchers reprogram human skin cells to aged neurons to study neurodegenerative disorders

Researchers have developed a new method for studying age-related brain disorders. The researchers have focused on the neurodegenerative disorder Huntington's disease.

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Scientists uncover a new role for blood-brain barrier in neuron function and damage

Researchers have made a surprising discovery linking Delta/Notch signaling in subperineurial glia (SPG) to the regulation of nerve ensheathment and neurotransmitter release at the Drosophila neuromuscular junction (NMJ). SPG, the counterpart of the endothelial layer in the vertebrate blood-brain barrier, form the key cellular layer that is critical for axonal ensheathment and the blood-brain barrier in Drosophila. The results provide a mechanistic insight into the biology of barrier function and glia-neuron interactions.

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Reprogramming the brain's cleaning crew to mop up Alzheimer's disease

The discovery of how to shift damaged brain cells from a diseased state into a healthy one presents a potential new path to treating Alzheimer's and other forms of dementia, according to a new study.

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Quality of life with multiple sclerosis may depend on several factors

Quality of life is a measure of a person's level of comfort, health and happiness. For people with multiple sclerosis (MS), a new study has found there are specific factors that may affect a person's physical and mental quality of life.

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New target identified for treatment of premature aging disease

A stretch of DNA that hops around the human genome plays a role in premature aging disorders, scientists have discovered. In people with early aging, or progeria, RNA encoded by this mobile DNA builds up inside cells. What's more, the scientists found that blocking this RNA reverses the disease in mice. The findings focus on a piece of RNA known as LINE-1.

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Dementia risk may be higher if an upper heart chamber is abnormal

A large, diverse study of over 5,000 older adults in the U.S. found that abnormal size or functioning in the left atrium (one of the two upper heart chambers), even before symptoms are present, may play a role in the development of dementia. The abnormalities, called atrial cardiopathy, appeared to increase participants' risk of developing dementia by 35%.

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Major contributor to Alzheimer's disease discovered

Research reports on a pathway that begins in the gut and ends with a potent pro-inflammatory toxin in brain cells contributing to the development of Alzheimer's disease (AD). They also report a potentially simple way to prevent it.

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How microglia contribute to Alzheimer's disease

A new study shows how a type of cells called microglia contribute to the slowdown of neuron activity seen in Alzheimer's disease. The study found that microglia that express the APOE4 gene, one of the strongest genetic risk factors for Alzheimer's disease, cannot metabolize lipids normally, leading to a buildup of excess lipids that interferes with nearby neurons' ability to communicate with each other.

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Genetics may predict bladder cancer immunotherapy response

Investigators have identified genetic signatures that could predict whether tumors in patients with bladder and other cancers will respond to immunotherapy.

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Education, job, and social life may help protect brain from cognitive decline

Why do some people with amyloid plaques in their brains associated with Alzheimer's disease show no signs of the disease, while others with the same amount of plaque have clear memory and thinking problems? Researchers looked at genetic and life course factors that may help create a 'cognitive reserve' that provides a buffer against the disease.

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Common viruses may be triggering the onset of Alzheimer's disease

Two common viruses lie dormant in neurons -- herpes simplex virus (HSV), and varicella zoster virus (VZV). Lab models of the human brain show that activation or re-infection of VZV can trigger neuroinflammation and wake up HSV, leading to accumulation of Alzheimer's linked proteins and neural decline.

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Microscopic blood vessel disease in the brain's white matter associated with worse cognition in Alzheimer's

Disease of the microscopic blood vessels that feed the white matter of our brain is associated with worse cognitive function and memory deficits in individuals with Alzheimer's, scientists report.

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New molecule may prevent age-related diseases and increase life expectancy and wellness, study suggests

Researchers have identified a group of molecules that enable cells to repair damaged components, making it possible for those tissues to retain proper function.

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Life expectancy drops for Native Americans due to COVID-19

The pandemic reduced Native American life expectancy at birth from the already low 72 years in 2019 to about 67 years in 2020 and about 65 years in 2021 for both sexes combined.

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