Thinning of brain region may signal dementia risk 5-10 years before symptoms

Researchers discover biomarker that could indicate dementia much earlier than its onset.

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Surprise discovery: For most animals, sperm quality does not reduce with age

In humans, male fertility and sperm fitness decline with age, but scientists have made the surprising discovery that this pattern is not consistent in other animals. The team assessed the results of 379 studies which covered a wide range of animals, including mammals, insects, birds, and fish.

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Third major study finds evidence that daily multivitamin supplements improve memory and slow cognitive aging in older adults

Researchers tested the effects of a daily multivitamin on cognitive changes in a study of 573 participants with in-person visits in the COSMOS trial. The researchers also conducted a meta-analysis among over 5,000 non-overlapping participants across the three separate cognition studies within the COSMOS trial. Results showed a statistically significant benefit for cognition among participants taking the multi-vitamin compared to placebo, suggesting that a multi-vitamin could help prevent memory loss and slow cognitive aging among older adults.

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Unraveling the role of supersulfides in regulating mitochondrial function and longevity

Supersulfides, many of which are produced by cysteinyl-tRNA synthetase (CARS), are essential compounds across many different lifeforms. However, the precise physiological roles of CARS-produced supersulfide are unclear. Now, using a strategically engineered yeast mutant with a deficient CARS gene, researchers from Japan have shown that supersulfides control cell longevity by mediating mitochondrial energy metabolism and regulating protein quality.

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Incontinence could point to future disability

Having more frequent urinary incontinence and leakage amounts is associated with higher odds of disability, according to researchers.

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Aging mouse sperm affects MicroRNA, increasing the risk of neurodevelopmental disorders

Much is known about the added complication to pregnancy when it comes to the age of the mother, but recent studies show that the age of the father can also heighten the risk of neurodevelopmental disorders. A team of researchers has explored the impacts of paternal aging on microRNAs, the molecules that play a crucial role in regulating gene expression.

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Stress, via inflammation, is linked to metabolic syndrome

A new study has found that stress, through its propensity to drive up inflammation in the body, is linked to metabolic syndrome -- leading researchers to suggest that cheap and relatively easy stress-management techniques may be one way to help improve biological health outcomes.

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Scientists identify how dietary restriction slows brain aging and increases lifespan

Restricting calories is known to improve health and increase lifespan, but much of how it does so remains a mystery, especially in regard to how it protects the brain. Scientists have now uncovered a role for a gene called OXR1 that is necessary for the lifespan extension seen with dietary restriction and is essential for healthy brain aging.

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Researchers discover potential microbiome links to skin aging

Recent findings have identified a potential new link to signs of skin aging -- the skin microbiome, the collection of microorganisms that inhabits our skin.

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RSV shown to infect nerve cells, cause inflammation and damage

RSV, a common infection in children and the elderly thought to only infect the respiratory tract, can also infect nerve cells and cause nerve damage, according to a new study. The findings could have major implications about whether RSV could be connected to neurological or developmental disorders.

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Prostate cancer: Newly-developed inhibitor shows massive potential

More than 65,000 men fall ill with prostate cancer each year in Germany. Twelve thousand of them develop a treatment-resistant form which eventually ends in death. Now, a team of researchers has developed an active substance that might in future represent a new treatment option. This substance, known as KMI169, targets an enzyme that plays an important role in the development of prostate cancer.

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Life span increases in mice when specific brain cells are activated

A new study identifies, in mice, a critical communication pathway connecting the brain and the body's fat tissue in a feedback loop that appears central to energy production throughout the body. The research suggests that the gradual deterioration of this feedback loop contributes to the increasing health problems that are typical of natural aging.

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Could a drug prevent hearing loss from loud music and aging?

A person's hearing can be damaged by loud noise, aging and even certain medications, with little recourse beyond a hearing aid or cochlear implant.

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Hearing loss increases the risk of dementia

In a new study featuring data from 573,088 people, researchers have found a link between hearing loss and the development of dementia. The study is the largest of its kind to date.

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Hearing aids may help people live longer

A new study shows that adults with hearing loss who regularly used hearing aids had a 24% lower risk of mortality than those who never wore them.

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Enlarged spaces in infant brains linked to higher risk of autism, sleep problems

Researchers have found that enlarged perivascular spaces in the brains of babies, caused by an accumulation of excess cerebrospinal fluid, have a 2.2 times greater chance of developing autism later in life.

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Even in midlife, disrupted sleep tied to memory, thinking problems later on

People who have more disrupted sleep in their 30s and 40s may be more likely to have memory and thinking problems a decade later, according to new research published in the January 3, 2024, online issue of Neurology , the medical journal of the American Academy of Neurology. The study does not prove that sleep quality causes cognitive decline. It only shows an association.

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Risk of young-onset dementia could be reduced through targeting health and lifestyle factors

Researchers have identified a wide range of risk factors for young-onset dementia. The findings challenge the notion that genetics are the sole cause of the condition, laying the groundwork for new prevention strategies.

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Early-life diseases linked to lifelong childlessness

A groundbreaking study reveals a significant association between 74 early-life diseases and the likelihood of remaining childless throughout one's life, with 33 of these diseases prevalent in both women and men.

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Very irregular sleep linked to higher risk of dementia

People who have very irregular sleep patterns may have a higher risk of dementia than those who have more regular sleep patterns, according to new research. The study does not prove that sleep irregularity causes dementia. It only shows an association.

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