Thursday, March 31, 2022

British Man Can Fill Up His Gas Tank For Less Than $10

Meet the man with Britain’s lowest fuel bill as he drives the world’s smallest car, which costs just £7 ($9) to fill up. Alex Orchin is seen buzzing round his village on his daily chores in his quirky blue Peel P50. The 5ft 11ins (180 meter) car enthusiast drives around in the tiny motor, posting […]

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High rate of diabetes, high blood pressure in Puerto Ricans linked to brain changes

The high rate of diabetes and high blood pressure combined in Puerto Rican people may be linked to structural changes in the brain, according to a new study.

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Wednesday, March 30, 2022

Alzheimer‘s: Amyloid and tau are a perilous couple

In the course of Alzheimer's disease, two proteins called 'amyloid' and 'tau' accumulate in the brain. A new study with more than 200 participants now provides insights into the interaction of these pathological phenomena. The data suggest that tau load in the brain impairs memory functions only when amyloid burden is also high. These findings therefore support therapeutic approaches aimed at removing amyloid from the brain in the early stages of Alzheimer's disease.

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10-Year-old Finds Medieval Priory Seal Within Minutes of Using Metal Detector and Gets $5,000 For it

A ten-year-old boy who found an 800-year-old medieval priory seal matrix with his metal detector has raked in a small fortune after it sold for £4,000 ($5,239). George Henderson was with his dad Paul when he stumbled across the ancient oval seal during a charity dig last November. The pair had been scouring a field […]

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Tuesday, March 29, 2022

How accelerated biological aging may cause bowel cancer

Scientists have shown how accelerated biological aging measured by an epigenetic clock may increase the risk of bowel cancer, according to a new report.

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Promising Alzheimer's drug may also improve memory in Down syndrome and normal aging

New research is breaking ground in repurposing an FDA-approved drug as a potential treatment in Down syndrome and normal aging. The results suggest that GM-CSF may improve cognitive function in people with Down syndrome. The drug sargramostim (GM-CSF, which stands for granulocyte-macrophage colony-stimulating factor) is also the first to show memory improvement in Alzheimer's patients in a phase II clinical trial. GM-CSF is a normal human protein that is safe and well-tolerated with over 30 years of FDA-approved use for other disorders.

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Monday, March 28, 2022

New information about amyloid filaments in neurodegenerative diseases

Researchers have helped identify that a common protein found in neurodegenerative diseases forms amyloid filaments in an age-dependent manner without a connection to disease.

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Less antibody diversity as we age

As we age, our immune system works less well. We become more susceptible to infections and vaccinations no longer work as effectively. A research team has investigated whether short-lived killifish also undergo aging of the immune system. Indeed, they found that as early as four months of age, killifish have less diverse circulating antibodies compared to younger fish, which may contribute to a generalized decrease in the immune function.

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Potential therapy may boost chemoimmunotherapy response in bladder cancer

Adding an anti-inflammatory medication to immunotherapy and standard chemotherapy drugs may provide long-term suppression of aggressive bladder tumor growth, according to a proof-of-concept study.

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Sunday, March 27, 2022

Danish Company Creates Children’s Book to Make Ukrainian Refugees Feel at Home – And it’s Adorable (LOOK)

As millions of Ukrainian women and children take refuge in other European nations, one inspiring act of kindness by the EU company, Mediabrands Content Studio in Denmark, is warming hearts and going viral. With Denmark already haven taken in thousands of refugees, the Mediabrands Studio was inspired to write and create a free children’s book […]

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Gordon Ramsay Shocks School Cafeteria Manager Who Called in to Talk Show Asking For Substitute Chef For the Day

A short-handed school cafeteria manager called into a BBC Radio 2 talk show asking for help in her kitchen—and everyone was stunned by what happened next. Tina Clarke had been listening to celebrity chef Gordon Ramsay talk about his latest TV show, Future Food Stars. Tina told the host Vernon Kay she was “cooking on […]

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Friday, March 25, 2022

Holocaust Survivors Reunite in Florida After a Labor Camp Friendship was Broken 80 Years Ago

Those who say there’s no such thing as destiny need to meet Jack Waksal and Sam Ron, victims who met during the Holocaust, and who met again 79 years later in South Florida. Having endured slave labor shoulder to shoulder in the Pionki Labor Camp in Poland, the two were separated after Waksal escaped into […]

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Thursday, March 24, 2022

Tuberculosis induces premature cellular aging

Researchers found that the cells of humans and animals who have recovered from tuberculosis had prematurely aged up to 12 to 14 years. It's possible that this premature cellular aging is one reason why survivors of tuberculosis have a high risk of mortality.

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Lipid and glucose levels at age 35 associated with Alzheimer's disease

Living your best life at 35, ignoring cholesterol and glucose levels, may impact your chances of getting Alzheimer's disease (AD) later in life. According to new research, lower HDL (high-density cholesterol) and high triglyceride levels measured in blood as early as age 35 are associated with a higher incidence of AD several decades later in life. Researchers also found that high blood glucose measured between ages 51-60 is associated with risk of AD in the future.

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Researchers Highlight the Silver Linings of the Pandemic Identified in Large Poll

Human beings, despite our predilection for drama, are exceptionally resilient creatures, and able to find the silver lining in almost everything. A recent study queried the American population to find out what they consider to be the upsides of the pandemic. A multi-disciplinary team from Harvard and Stanford conducted interviews of 3,113 participants over the […]

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Wednesday, March 23, 2022

Researchers discover intake of FDA-approved drug modulates disease progression in Alzheimer’s disease model

Researchers found that niacin limits Alzheimer's disease progression when used in models in the lab, a discovery that could potentially pave the way toward therapeutic approaches to the disease.

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Tuesday, March 22, 2022

Chronologically young, biologically old: DNA linked to cancer survivors premature aging

Scientists have identified variants in two genes that are associated with accelerated aging in childhood cancer survivors.

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Novel heart ultrasound measures can be used to predict risk of developing dementia

New research assessed if there is a link between heart health and dementia.

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Chronologically young, biologically old: DNA linked to cancer survivors premature aging

Scientists have identified variants in two genes that are associated with accelerated aging in childhood cancer survivors.

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Ukraine Inspires Humanity And Hope: 8 Positive Stories From the Conflict

From charities and governments, to celebrities and everyday people, millions are pitching in to ease the burden for fleeing or sheltering Ukrainians. In turn, they’re inspiring the world with their generosity and strength. We searched the internet to find heartwarming positive stories about Ukraine, and hope they will be an antidote to the daily barrage […]

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Monday, March 21, 2022

The secret to staying young: New research highlights power of life long exercise to keep muscles healthy

Lifelong physical activity could protect against age-related loss of muscle mass and function, according to new research. Individuals aged 68 and above who were physically active throughout their life have healthier aging muscle that has superior function and is more resistant to fatigue compared to inactive individuals, both young and old. This is the first study to investigate muscle, stem cell and nerve activity in humans. The researchers from University of Copenhagen, Denmark, found that elderly individuals who keep physically active throughout their adult life, whether by taking part in resistance exercise, ball games, racket sports, swimming, cycling, running and/or rowing had a greater number of muscle stem cells, otherwise known as satellite cells in their muscle. These cells are important for muscle regeneration and long-term growth and protect against nerve decay.

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Study shows that intranasal Rx halts memory decay in experimental Alzheimer’s model

A research collaboration has found that applying specialized pro-resolving lipid mediators intranasally arrested memory loss and brain degeneration in an experimental model of Alzheimer's Disease (AD).

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Saturday, March 19, 2022

UK’s Most Premature Twins Finally Go Home 5 Months After Being Given 0% Chance of Survival

‘The UK’s most premature twins’ have finally headed home from the hospital—five months after their birth when they were given a zero percent chance of survival. Little Harley and Harry Crane were conceived via IVF and were born at 22 weeks and five days. Babies born after only five months of development are not classed […]

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Friday, March 18, 2022

New strategy reduces brain damage in Alzheimer’s and related disorders, in mice

Alzheimer's disease is the most common and best known of the tauopathies, a set of neurodegenerative brain diseases caused by toxic tangles of the protein tau. A study has now shown that targeting astrocytes -- an inflammatory cell in the brain -- reduces tau-related brain damage and inflammation in mice.

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Strangers are Leaving Strollers, Diapers, and Toys at the Border for Ukrainian Refugee Moms (LOOK)

An image recently shared around social media of empty strollers on a Polish rail border crossing has inspired a mountain of donations for Ukrainian refugees. Now at PrzemyÅ›l Station, women, children, and infants fleeing the war are being greeted by mountains of clothes, stuffed animals, strollers, diapers, and more after they step off the train. […]

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How gene expression changes in the brain in Alzheimer's disease

An international group of researchers analyzed the genes that are expressed in neurons and astrocytes based on data from 800 individuals and compared what happens in Alzheimer's patients and in people without diagnosed dementia. The study highlights the need to analyze molecular markers, such as genetic sequences or brain proteins, to obtain more accurate assays, diagnoses and therapies. The results also show changes in astrocytes in an attempt to adapt to the toxic environment derived from the disease, worsening its progression.

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Extended napping in seniors may signal dementia

Daytime napping among older people is a normal part of aging -- but it may also foreshadow Alzheimer's disease and other dementias. And once dementia or its usual precursor, mild cognitive impairment, are diagnosed, the frequency and/or duration of napping accelerates rapidly, according to a new study.

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Thursday, March 17, 2022

Lithium may decrease risk of developing dementia

Researchers have identified a link suggesting that lithium could decrease the risk of developing dementia, which affects nearly one million people in the UK.

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Plasma biomarker screening could improve accuracy, health equity in Alzheimer’s disease diagnosis

A new study focuses on RNA molecules in plasma as biomarkers for Alzheimer's disease in African Americans -- the population at greatest risk for developing Alzheimer's disease. This approach enabled researchers to pinpoint specific molecules in plasma that could serve as biomarkers to confirm a diagnosis of Alzheimer's disease in this population.

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Alzheimer’s: Protective immune cells active decades before symptom onset

In individuals with a genetic predisposition to Alzheimer's disease, the immune cells of the brain -- the 'microglia' -- start exerting a protective effect up to two decades before the first symptoms appear. A team draws this conclusion based on a study of more than 200 volunteers. In light of their study data, the scientists consider modulating the activity of microglia to be a promising therapeutic approach. To this end, they aim to develop drugs that target a cellular receptor called TREM2.

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UPDATE: Airbnb and its Community Raise More Than $40 Million and Offers 150,000 Temp-Homes for Ukraine

GNN reported earlier this month that from March 2nd to March 3rd, people from around the world booked 61,000 nights in Ukrainian cities via Airbnb, likely not one ever planning to check-in, or reschedule. It was part of a creative social media campaign to channel funds into besieged cities where something like aid drops or […]

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Wednesday, March 16, 2022

Mechanism underlying Alzheimer-like damage in the brain of patients with Down Syndrome elucidated

Precisely why Alzheimer-like changes -- marked by the build-up of harmful amyloid and tau proteins -- occur in the brain in Down syndrome has been unclear. But now, in new research, scientists show that reduced efficiency of a key protein transport system is partly to blame.

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Tuesday, March 15, 2022

'Healthspan' increasing even for people with common chronic conditions

The number of healthy years a person lives is, on average, increasing even for people with common chronic conditions, according to a new study.

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Senolytic drugs boost key protective protein

Researchers say senolytic drugs can boost a key protein in the body that protects older people against aspects of aging and a range of diseases. Their findings demonstrate this in mice and human studies.

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Monday, March 14, 2022

Cognitive decline key factor in predicting life expectancy in Alzheimer’s disease

Cognitive decline is the biggest factor in determining how long patients with Alzheimer's disease will live after being diagnosed, according to a new study.

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Elementary Students Give You Pep Talks on Recorded Phone Line: The ‘Peptoc Hotline’

It’s sometimes said that “wisdom oft comes from the mouths of babes,” but what it doesn’t mention is that you have to dial 1 first. A new telephone hotline is relieving stress and lightening moods with laughter, words of encouragement, and advice from elementary school students—and it’s ringing off the hook. The Peptoc Hotline was […]

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History of neurological or psychiatric conditions increases the likelihood of developing more

People living with neurological or psychiatric conditions may have an increased likelihood of having a second such condition in the future, and their sex influences their risk, according to new research.

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Sunday, March 13, 2022

Volunteers Ease Loneliness For Seniors, Giving Rides With 3,700 Couches-On-Wheels Worldwide

In cities across the world, volunteers are taking the elderly and people with disabilities out for spins on special tricycles to enjoy the great outdoors. Cycling Without Age (CWA) is riding again following the relaxation of COVID-19 restrictions in Scotland—and they are delighted to be providing their scientifically-proven method of enhancing well-being for seniors. Cycling Without […]

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Saturday, March 12, 2022

Man Finally Receives Grandfather’s Purple Heart Awarded 75 Years Ago, After Stranger Searches to Find Her 2nd Cousin

Jeff Hertzog was recently contacted by a stranger who searched tirelessly so she could return his grandfather’s Purple Heart war medal. She is not just any stranger, however. She turned out to be a second cousin, and the act of kindness brought together members of their families who had never met. The Purple Heart was […]

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Friday, March 11, 2022

Exercise may treat long COVID-induced diabetes, depression

While no medically recognized treatment exists for long COVID, exercise may break the vicious cycle of inflammation that can lead to developing diabetes and depression months after a person recovers from the virus.

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How a touch-sensing protein could stop constipation

When we eat food, our gut somehow senses its presence to begin shifting it along our digestive tract, but the question has always been -- how? Now, new research using both human gut samples and mice has discovered that a touch-sensing protein called Piezo2 is not just in our fingers, but also in our gut, with its presence likely playing a key role in constipation.

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Thursday, March 10, 2022

Damage to inner ear system predicts fall risk among people with Alzheimer's disease

A study of about 50 people with Alzheimer's disease has added to evidence that damage to the inner ear system that controls balance is a major factor in patients' well-documented higher risk of falling.

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The cellular cleaning program autophagy helps in wound healing

Scientists have shown that the recycling program of cells, autophagy, leads to the fusion of several single cells into multinucleated cell units during wound healing.

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Canadian Millionaire Donates His Life Savings to Plant 100,000 Daffodils – And They’ve Just Begun to Bloom

More than 100,000 daffodils planted in a town as part of a generous gift from a Canadian banker in his will are finally beginning to bloom. The valley of bulbs were planted after a dying wish by Keith Owen, who planned to retire in Sidmouth in Devon, southwest England. He was diagnosed with terminal cancer […]

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Blood test as possible diagnostic tool for Alzheimer’s disease

A recent study shows promising results for a blood test that could be used to identify Alzheimer's changes in the brain before the onset of any symptoms, which could result in preventative treatments being used before any memory loss.

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Could leaky blood vessels in the brain be a culprit in Alzheimer’s disease?

Researchers report that they found high levels of the protein Fli-1 in the brains of deceased Alzheimer's patients. Blocking Fli-1's action in a mouse model of Alzheimer's disease reversed mental loss and reduced the brain inflammation and amyloid-beta clumping that are hallmarks of Alzheimer's disease. Although clinical translation of this finding is likely years off, the study suggests Fli-1 is a promising therapeutic target for Alzheimer's disease.

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People Around the World Are Booking Airbnb Rooms in Ukraine Raising Millions for People Under Siege or Fleeing

From March 2nd to March 3rd, people from around the world booked 61,000 nights in Ukrainian cities via Airbnb, likely not one ever planning to check-in, or reschedule. It’s part of a creative social media campaign to channel funds into besieged cities where something like aid drops or supply trucks can’t reach, and it has […]

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Sleep apnea accelerates aging, but treatment may reverse it

Obstructive sleep apnea (OSA) affects 22 million people in the U.S. and is linked to a higher risk of hypertension, heart attacks, stroke, diabetes and many other chronic conditions. But now researchers have found that untreated OSA also accelerates the biological aging process and that appropriate treatment can slow or possibly reverse the trend.

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Wednesday, March 9, 2022

In pilot study, asynchronous telehealth visits effectively treat overactive bladder

Women with overactive bladder are frequently frustrated with treatment, which leads to discontinuation of therapy. Asynchronous telehealth visits keep women engaged in follow-up care, accelerates trials of different medications and reinforces behavioral changes. The women in this pilot study reported improvement in symptoms and high satisfaction with asynchronous visits.

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Some of the world’s lowest rates of dementia found in Amazonian indigenous groups

A new study reveals that two indigenous groups in the Bolivian Amazon have among the lowest rates of dementia in the world. An international team of researchers found among older Tsimane and Moseten people, only about 1% suffer from dementia. In contrast, 11% of people age 65 and older living in the United States have dementia, according to the Alzheimer's Association.

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Tuesday, March 8, 2022

Optimistic Men Have a Better Shot at Less-Stressful, Healthy Aging, Finds New Study

“Don’t worry, be happy,” is more than just a song lyric. A growing body of evidence supports an association between optimism and healthy aging. A new study has found that being more optimistic appears to promote emotional well-being by limiting how often older men experience stressful situations, like arguments, or effecting the way they interpret […]

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Physical activity may protect your brain as you age

We all know we should exercise and eat healthy foods. But doing that isn't just good for maintaining your figure as you age. New research shows that physical activity could help protect your cognitive abilities as you age. And it doesn't have to be intense exercise to make an impact.

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Distinct biological ages across individuals’ various organs and systems

It's common to say that someone looks either younger or older than their chronological age, but aging is more than skin deep. Our various organs and systems may have different ages, at least from a biological perspective. Investigators used biomarkers, statistical modeling, and other techniques to develop tools for measuring the biological ages of various organ systems. Based on their findings, the researchers report that there are multiple 'clocks' within the body that vary widely based on factors including genetics and lifestyle in each individual.

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Digital toolbox may help diagnose dementia earlier

Detecting cognitive changes early in the onset of dementia would be a game-changer for thousands impacted by the disease and would allow for interventions well before significant brain changes occur. While cognitive function is often measured using paper and pencil tests with scores calculated by the number of correct answers, this number (score) omits a lot of information about the process a person uses to answer a question that might reveal important information about their brain function.

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Protect against aging and age-related disease with the MondoA protein

Researchers have shown that a protein called MondoA can activate the important health-linked process of autophagy, whereby cells are broken down and their components are recycled. MondoA both inhibited a protein called Rubicon and regulated the Prdx3 protein, which maintains the stability of energy-producing mitochondria within cells. Activation of MondoA protected against aging and age-associated kidney injury, indicating its potential as a target for the treatment of aging and age-related diseases.

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Monday, March 7, 2022

Lead exposure in last century shrank IQ scores of half of Americans, study finds

Researchers calculate that exposure to car exhaust from leaded gas during childhood stole a collective 824 million IQ points from over 170 million Americans alive today, more than half of the population of the United States.

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Cellular rejuvenation therapy safely reverses signs of aging in mice

Age may be just a number, but it's a number that often carries unwanted side effects, from brittle bones and weaker muscles to increased risks of cardiovascular disease and cancer. Now, scientists have shown that they can safely and effectively reverse the aging process in middle-aged and elderly mice by partially resetting their cells to more youthful states.

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Friday, March 4, 2022

Possible common thread between many neurodegenerative diseases

Researchers reveal a new fibril in diseased brains, one formed by a protein normally busy cleaning cells.

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Researchers find 'genetic baggage' accumulates in the genomes of aging mutant animals

You are probably familiar with the term that some people carry 'a lot of extra baggage.' Usually that term refers to that person's emotional history, but in genetics and our genomes, 'extra baggage' can also describe the transposons lurking in our genomes, a historical record of our genomes surviving traumatic invasions during evolution. Transposons are repetitive DNA sequences that have the capability to move (transpose) from one location to another in the genome (an organism's complete set of genetic instructions) and are considered important invaders of our genomes during evolution.

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Ukraine Receives Truckload of Starlink Terminals From Elon Musk For Uninterrupted Internet

Elon Musk has sent a truckload of necessary equipment for his Starlink service to Ukraine, at the request of a government minister. With the country’s telecommunications infrastructure under attack by the Russian air force, maintaining connectivity to the internet is challenging. Starlink is a satellite internet service which Musk’s company SpaceX has pioneered to provide […]

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Thursday, March 3, 2022

Extending the longevity of stem cells

People are having children later than ever before. The average age of new parents in the United States has been rising for at least the past half century. But time is tough on our bodies and our reproductive systems. For instance, as animals age, our stem cells are less effective at renewing our tissues. This is particularly true for germline stem cells, which turn into sperm and eggs. What if there were a way to pause this process?

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Former Marine Drove 1,000 Miles to Ukraine Border in Minibus Loaded with Supplies, Toys, and Blankets for Refugees

A former UK Royal Marine has loaded a 16-seater minibus with sleeping bags, pillows, and toys for refugees moving across the Ukrainian border into Poland, and pledged to drive 1,000 miles to personally deliver them. 31-year-old Tom Littledyke from Lyme Regis began his journey on February 28th, saying he was inspired to act after seeing […]

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Wednesday, March 2, 2022

Early menopause may raise risk of dementia later in life

Compared with women who enter menopause around age 50, women who experience very early menopause (before the age of 40) were found to be 35% more likely to develop some type of dementia later in life, according to a large study of women living in the United Kingdom. Women who entered menopause before age 45 were also 1.3 times more likely to develop dementia before the age of 65. In addition, women who entered menopause later, at age 52 or older, had dementia risk similar to women who entered menopause at the average age for menopause onset which is the age of 50 to 51 years.

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He Was Quoted $50,000 to Fix the Church Clock But All it Took Was a Can of WD-40

Grimsby is a large port town in Lincolnshire where a 14th-century church clock has been stuck at two-past-twelve for twelve years. Recently, when the church minister decided to see about getting it repaired, a pair of clock engineers gave quotes that wouldn’t look out of place next to the ‘for sale’ sign beside a brand […]

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Tuesday, March 1, 2022

The role of lipids in the development of Alzheimer’s disease

Neurons in the brain coexist with and rely on many other cell types to function properly. Astrocytes, which take their name from their star shape, ensure the survival of neurons by feeding and detoxifying them with the help of a multifunctional protein, APOE. One of three forms of this protein, APOE4, significantly increases the risk of developing Alzheimer's disease, but the mechanisms at play are unknown.

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