With fractured genomes, Alzheimer's neurons call for help

Ailing neurons plagued with an accumulation of double-strand breaks in their DNA may instigate an inflammatory response from the brain's microglia immune cells, a new study shows.

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One in three Alzheimer's disease family caregivers has persistent symptoms of depression

More than 60% of family caregivers of individuals with Alzheimer's disease (AD) experienced at least mild depressive symptoms already at the time the individual with AD was diagnosed. In one third of them, depressive symptoms worsened during a five-year follow-up.

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Breaks in 'junk' DNA give scientists new insight into neurological disorders

'Junk' DNA could unlock new treatments for neurological disorders as scientists discover its breaks and repairs affect our protection against neurological disease.

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John Cena Smashes Guinness World Record – Granting 650 Wishes for Sick Children

American actor and WWE superstar John Cena has set a new record for the most wishes granted through the Make-A-Wish Foundation with 650. The Make-A-Wish Foundation helps fulfill the wishes of children who have been diagnosed with a critical illness. As the most wished-for celebrity, nobody else has ever granted more than 200 wishes in the 42-year […]

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Youth Crime in the U.S. Has Plummeted 78% Since 1994, Which Counters the Usual Narrative

A recent report found that the number of youth arrests for violent crime continued to decline in 2020 and was down 78% from its peak in 1994. Analysis of the data from the FBI found that people aged 17 and younger accounted for just 7% of all arrests for violent crime like murder and robbery […]

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Fasting-mimicking diet reduces signs of dementia in mice

Cycles of a diet that mimics fasting appear to reduce signs of Alzheimer's in mice genetically engineered to develop the illness, according to a new study. Short cycles of a low-calorie diet that replicates fasting appeared to reduce inflammation and delay cognitive decline in mouse models of Alzheimer's disease; initial data indicates diet's safety in Alzheimer's patients.

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Disarming the immune system's lethal lung response

Neutrophils are the body's first line of defense against infection. But if too many attack for too long, they can damage the tissues they're meant to protect. In the lungs, this damage can lead to acute respiratory distress syndrome, the leading cause of death due to COVID-19. Researchers have found that using a drug to inhibit a protein called PTP1B can prevent lethal lung inflammation in mice. This discovery may lead to better treatments for severe inflammatory conditions like sepsis and COVID-19.

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COVID-19 associated with increase in new diagnoses of type 1 diabetes in youth, by as much as 72 percent, study finds

Children who were infected with COVID-19 show a substantially higher risk of developing type 1 diabetes (T1D), according to a new study that analyzed electronic health records of more than 1 million patients ages 18 and younger.

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How does what we eat affect our healthspan and longevity? It's a complex dynamic system

The answer to a relatively concise question -- how does what we eat affect how we age -- is unavoidably complex, according to a new study. While most analyses had been concerned with the effects of a single nutrient on a single outcome, a conventional, unidimensional approach to understanding the effects of diet on health and aging no longer provides us with the full picture: healthy diet needs to be considered based on the balance of ensembles of nutrients, rather than by optimizing a series of nutrients one at a time. Until now little was known about how normal variation in dietary patterns in humans affects the aging process.

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More older adults should be checking blood pressure at home, study suggests

Only 48 percent of people age 50 to 80 who take blood pressure medications or have a health condition that's affected by hypertension regularly check their blood pressure at home or other places, a new study finds. A somewhat higher number -- but still only 62 percent -- say a health care provider encouraged them to perform such checks.

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Researchers advance efforts to tailor drug delivery to cells' 'power plants'

In a study using lab-grown cells, researchers specializing in aging report they have successfully delivered a common blood pressure drug directly to the inner membrane of mitochondria, the 'power plants' in the cells of humans, animals, plants and most other organisms.

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Former Debt Collectors Have Wiped Away $6.7 Billion of Medical Debt for Millions of Americans

A dynamic duo from Wall Street has just passed a huge milestone in charitable history, completely paying off the medical debt for some 3.6 million Americans—a do-good revolution from two guys who used to be debt collectors themselves. It was the Occupy Wall Street movement that first stirred the hearts of Jerry Ashton and Craig […]

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Former Debt Collectors Have Wiped Away $6.7 Billion of Medical Debt for Millions of Low-Income Americans

The country’s largest charity for paying off medical debt has just passed a huge milestone that leaves the jaw agape—3.6 million Americans whose medical debt has been zeroed by, of all people, two former Wall Street debt collectors. It was 2011’s Occupy Wall Street movement that first stirred the hearts of Jerry Ashton and Craig […]

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COVID-19 infections increase risk of long-term brain problems

A comprehensive analysis of federal data shows people who have had COVID-19 are at an elevated risk of developing neurological conditions within the first year after infection. Movement disorders, memory problems, strokes and seizures are among the complications.

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Artificial intelligence used to uncover the cellular origins of Alzheimer's disease and other cognitive disorders

Deep learning models represent 'an entirely new paradigm for studying dementia.'

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Newly identified small molecules break amyloid tangles that cause Alzheimer's

In lab experiments, researchers observed a molecule called EGCG break up tau tangles extracted from Alzheimer's disease brain tissue EGCG does not, however, easily penetrate the human brain. They found two other molecules -- CNS-11 and CNS-17 -- that work like EGCG to stop tangles spreading cell to cell but are better leads for drugs.

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Nightmares in middle age linked to dementia risk

People who experience frequent bad dreams in middle age are more likely to be diagnosed with dementia later in life, according to research at the University of Birmingham.

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Southwest Airlines Workers Looked After a Passenger’s Pet Fish for 4 Months After it was Banned From Flight

A pair of Southwest Airline employees volunteered to become mom and dad to a passenger’s fish after the passenger was told she could not embark with the animal. Kira was returning home from her Freshman year at college with her beta fish Theo when she was told it was not allowed on her flight. That’s […]

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Genetic variants linked to congenital urinary tract obstruction in males

Genetic variation affecting developmental genes not previously linked to urethral development may contribute to a congenital condition that is the most common cause of kidney failure in young males, a new study suggests.

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He Invented a $2 Paper Microscope For Remote Lab Work So Scientists Don’t Have to Haul Heavy Equipment

A young scientist who worked in the jungles of Thailand has been awarded a national prize for his invention of a $2 paper microscope that can be taken on field expeditions. If a scientist wants to study something at the microscopic level, they need a microscope, which if they are deep in the Amazon Rainforest […]

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New study explains link between diabetes and UTIs

Lower immunity and recurring infections are common in type 1 and type 2 diabetes. Researchers now show that the immune system of people with diabetes has lower levels of the antimicrobial peptide psoriasin, which compromises the urinary bladder's cell barrier, increasing the risk of urinary tract infection.

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Nebraska Man Makes World’s Longest Journey by Pumpkin Boat on 60th Birthday

On the morning of August the 27th, a Nebraska man woke up on his 60th birthday with a single goal—to raft the mighty Missouri in a giant pumpkin. This is not the start to a collaborative work between Roald Dahl and Mark Twain, but rather the Guinness World Record-breaking stunt by giant pumpkin enthusiast Duane […]

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Toddler Given Cancer Prognosis of 6-12 Months Defies the Odds to be Declared Cancer-Free in 8 Months

A toddler given a prognosis of six to 12 months to live after doctors found a tumor has defied the odds and been declared cancer-free. In April of 2021, Leanne Waite and her husband, Chris, were dressing their three-year-old son when they noticed his left arm was in severe pain after it got caught in […]

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New Poll Reveals The Secret to Happiness is Practicing Gratitude

The secret to maximum happiness may be expressing gratitude, a new poll suggests. The random double-opt-in survey of 2,000 Americans looked at the potential connection between gratitude and happiness — revealing that 65% of respondents who report that they’re “very happy” on a daily basis were more likely to “always” give thanks. While looking at […]

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The Guam Kingfisher Could Soon Return to the Wild After a 30-Year Absence Thanks to Ambitious Scientists

A long shot rescue plan for the Critically-Endangered Guam kingfisher is set to take place on the wilds of an island nowhere near Guam. Having been extirpated from Guam via invasive brown tree snakes, captive breeding centers have kept the species treading water until now. A scientific mission born of a partnership between the Nature […]

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Repeated infections associated with increased risk of some neurodegenerative diseases

Infections treated with specialty hospital care in early- and mid-life are associated with an increased subsequent risk of Alzheimer's (AD) and Parkinson's diseases (PD), but not amyotrophic lateral sclerosis (ALS), according to a new study.

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Daily multivitamin may improve cognition and possibly protect against decline, study suggests

New research shows that taking a daily supplement may improve cognition in older adults. In the study, researchers estimated that three years of multivitamin supplementation roughly translated to a 60-percent slowing of cognitive decline (about 1.8 years).

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Researchers identify immune cell that helps kill bladder cancer tumors

Researchers have made two important discoveries about the mechanism by which bladder cancer cells foil attacks from the immune system. The research could lead to a new therapeutic option for patients with these types of tumors.

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Author Spends Lifetime Searching for Woman Who Taught Him to Read, and Then She Surprised Him

Author Jamil Jan Kochai tried for years to reconnect with his second grade teacher—a woman whom he credits with all the success he has had in life. Why is this? Mrs. Lung stayed after hours in their Sacramento elementary school to teach Kochai one-on-one how to read and write, something she managed in a just […]

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Risk factor for developing Alzheimer's disease increases by 50-80% in older adults who caught COVID-19

Older people who were infected with COVID-19 show a substantially higher risk -- as much as 50% to 80% higher than a control group -- of developing Alzheimer's disease within a year, according to a study of more than 6 million patients 65 and older.

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New research estimates the overall disease burden of genetic risk factors

Researchers have, for the first time, systematically estimated the impact of a range of different disease-associated genetic risk factors on the loss of healthy life years. Knowing the contribution of different genetic risk factors on disease burden can help prioritise and design interventions using genetic information.

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Significant risk of sensory loss in long COVID, study finds

New research has revealed the extent of sensory loss among people suffering from long COVID, with around 30 percent reporting a decreased sense of smell, and a similar number finding their sense of taste continuing to be affected 12 weeks or more after the initial infection.

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Man Tracks Down Teen Who Mugged His Nephew to See if He Would Turn His Life Around

A man tracked down the teen knifeman who mugged his nephew and rather than hand him in, spoke to him about turning his life around. After listening to the remorseful youth’s story, Winston Davis has been inundated with job offers for the lad to keep him away from crime. It took Davis six weeks to […]

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Scientists discover how cells repair longevity-promoting 'recycling system'

Researchers described a pathway by which cells repair damaged lysosomes, structures that contribute to longevity by recycling cellular trash. The findings are an important step towards understanding and treating age-related diseases driven by leaky lysosomes.

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High blood pressure may accelerate bone aging

A new study in mice found that hypertension may be linked to significant bone loss. Bone quality in young mice with high blood pressure was similar to the bones of older mice without high blood pressure, suggesting that the effects of hypertension on bone quality, which includes strength, may mimic that of aging. The researchers suggest early detection and treatment of high blood pressure may help to deter loss of bone quality as people age.

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How a single protein could unlock age-related vision loss

Researchers are helping to reveal the molecular secrets of macular degeneration, which causes almost 90% of all age-related vision loss.

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Grandma Lost 250 Pounds and is Now a Bodybuilder After Saggy Skin Removal

Unable to get around without a walker, an English Granny has gone on to shed 250 pounds, have 28 pounds of saggy skin removed, and is now a professional bodybuilder. Years ago, Dee Hodgson’s size used to leave her in constant agony, and doctors suspected she was suffering from fibromyalgia, a long-term condition that causes […]

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Pakistan’s First Female Architect Brings Bamboo-Built Relief Shelters to Flood-Risk Areas

Everyone needs a pension project, and for the first-ever female architect in Pakistan, hers has taken on a critical infrastructure need—disaster relief housing. Yasmeen Lari, now 81, is the cofounder of a nonprofit called the Heritage Foundation of Pakistan, which is making bamboo huts for Pakistanis stricken by floods. Spending most of her career designing […]

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Insomnia increases the likelihood of memory decline in older adults, according to new research

A new study has found that older people with insomnia are at greater risk of developing memory decline and long-term cognitive impairment such as dementia.

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Long-Lost Brothers to Be Reunited After 77 Years and 10,000 Miles, ‘I still can’t believe it’ (WATCH)

A pair of long-lost brothers who were separated as children in 1945 are to be reunited for the first time after 77 years apart. Ted Nobbs, 83, and his brother Geoff, 79, have spent more than seven decades 10,000 miles apart after their family was divided up at the end of the Second World War. […]

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Friends Saved Over a Million Gallons of Paint From Landfill by Rescuing and Remixing it to Give it New Color

Meet the friends who have saved more than 1.05 million gallons of paint from landfills by rescuing used cans—refilling and remixing them to give each one a new lease of life. Cat Hyde and Kate Moree had the passion and drive to make a difference by repurposing waste material, while making money at the same […]

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Good News in History, September 3

Happy 65th Birthday to Sadhguru Jagadish Vasudev, the yoga-teacher, speaker, proponent of regenerative agriculture, and other social causes. Born in the Indian state of Mysore, he has been teaching yoga in southern India since 1982, but it was in the 90s that his talent for inspiring collective action was realized with the foundation of his […]

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Circadian rhythm disruption found to be common among mental health disorders

Scientists hypothesize that circadian rhythm disruption is a psychopathology factor shared by a broad range of mental illnesses and that research into its molecular foundation could be key to unlocking better therapies and treatments.

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New method could aid Alzheimer's research by predicting risk before symptoms start

Researchers have developed a new method to identify people who are at greater genetic risk of developing Alzheimer's disease, before any symptoms appear -- which could help speed creation of novel treatments.

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